Diabetic kidney disease in 2017

A new era in therapeutics for diabetic kidney disease

2017 saw the emergence of a new era in renoprotective medicine for diabetic kidney disease with reports of promising renal outcomes with the sodium–glucose cotransporter 2 (SGLT2) inhibitors empagliflozin and canagliflozin from follow-up analyses of the EMPA-REG OUTCOME trial and the CANVAS Program, respectively, and with use of the glucagon-like peptide 1 (GLP1) agonist liraglutide in the LEADER trial.

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Figure 1: Effects of SGLT2 inhibition and GLP1 agonism on renal haemodynamics in diabetes mellitus.


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Correspondence to Christoph Wanner.

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Competing interests

C.W. has received honoraria for consultancy and speaking from Boehringer-Ingelheim, Sanofi-Genzyme, Astra-Zeneca and Mitsubishi Pharma.

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Wanner, C. A new era in therapeutics for diabetic kidney disease. Nat Rev Nephrol 14, 78–80 (2018). https://doi.org/10.1038/nrneph.2017.182

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