Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Hypertension in 2017

Novel mechanisms of hypertension and vascular dysfunction

New findings in 2017 enhanced our understanding of the mechanisms that regulate blood pressure. Key studies provided insights into immune mechanisms, the role of the gut microbiota, the adverse effects of perivascular fat and inflammation on the vasculature, and the contribution of rare variants in renin–angiotensin–aldosterone system genes to salt sensitivity.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Novel mechanisms of hypertension and aortic aneurysm formation.


  1. 1

    Whelton, P. K. et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension (2017); J. Am. Coll. Cardiol. (2017).

  2. 2

    Madhur, M. S. et al. Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension 55, 500–507 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Wu, C. et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513–517 (2013).

    CAS  Article  Google Scholar 

  4. 4

    Norlander, A. E. et al. A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. JCI Insight 2, e92801 (2017).

    Article  Google Scholar 

  5. 5

    Wilck, N. et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551, 585–589 (2017).

    CAS  Article  Google Scholar 

  6. 6

    Caillon, A. et al. Gamma/delta T cells mediate angiotensin II-induced hypertension and vascular injury. Circulation 135, 2155–2162 (2017).

    CAS  Article  Google Scholar 

  7. 7

    Sakaue, T. et al. Perivascular adipose tissue angiotensin II type 1 receptor promotes vascular inflammation and aneurysm formation. Hypertension 70, 780–789 (2017).

    CAS  Article  Google Scholar 

  8. 8

    He, J. et al. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. Circ. Cardiovasc. Genet. 6, 598–607 (2013).

    CAS  Article  Google Scholar 

  9. 9

    Kelly, T. N. et al. Resequencing study identifies rare renin–angiotensin–aldosterone system variants associated with blood pressure salt-sensitivity: the GenSalt study. Am. J. Hypertens. 30, 495–501 (2017).

    CAS  Article  Google Scholar 

Download references


The work of the author was funded by Canadian Institutes of Health Research (CIHR) First Pilot Foundation Grant 143348 and a tier 1 Canada Research Chair on Hypertension and Vascular Research by the Canada Research Chair CIHR/Government of Canada Program.

Author information



Corresponding author

Correspondence to Ernesto L. Schiffrin.

PowerPoint slides

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schiffrin, E. Novel mechanisms of hypertension and vascular dysfunction. Nat Rev Nephrol 14, 73–74 (2018).

Download citation

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing