Studies of cellular energetics have revealed important roles of metabolic pathways in determining cell fate and response to injury. Insights from 2017 into the mechanisms underlying these pathways might identify therapeutic targets to minimize injury and promote repair.
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Cantelmo, A. R. et al. Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy. Cancer Cell 30, 968–985 (2016).
Ochocki, J. D. & Simon, M. C. Nutrient-sensing pathways and metabolic regulation in stem cells. J. Cell Biol. 203, 23–33 (2013).
Liu, J. et al. Regulation of nephron progenitor cell self-renewal by intermediary metabolism. J. Am. Soc. Nephrol. 28, 3323–3333 (2017).
Combes, A. N., Lefevre, J. G., Wilson, S., Hamilton, N. H. & Little, M. H. Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip. Dev. Biol. 418, 297–306 (2016).
Lan, R. et al. Mitochondrial pathology and glycolytic shift during proximal tubule atrophy after ischemic AKI. J. Am. Soc. Nephrol. 27, 3356–3367 (2017).
Han, S. H. et al. PGC-1α protects from notch-induced kidney fibrosis development. J. Am. Soc. Nephrol. 28, 3312–3322 (2017).
Gugliucci, A. Formation of fructose-mediated advanced glycation end products and their roles in metabolic and inflammatory diseases. Adv. Nutr. 8, 54–62 (2017).
Andres-Hernando, A. et al. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat. Commun. 8, 14181 (2017).
Sas, K. M. et al. Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complication. JCI Insight 1, e86976 (2016).
Qi, W. et al. Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction. Nat. Med. 23, 753–762 (2017).
The authors declare no competing financial interests.
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Rabelink, T., Carmeliet, P. Glycolytic adaptation and progression of kidney disease. Nat Rev Nephrol 14, 75–76 (2018). https://doi.org/10.1038/nrneph.2017.173
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