Glomerular disease

Immunosuppressant-induced reduction of proteinuria in IgAN

Time-averaged proteinuria (TAP) is thought to be the most reliable predictor of outcomes in IgA nephropathy (IgAN). New data suggest that corticosteroids reduce TAP and presumably improve outcomes in IgAN, but increase the risk of adverse effects. Whether TAP is a good surrogate end point for clinical trials remains unclear.

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Figure 1: Trial-level assessment of the validity of proteinuria as a surrogate end point in IgAN.

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Correspondence to Jürgen Floege.

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Floege, J., Rauen, T. Immunosuppressant-induced reduction of proteinuria in IgAN. Nat Rev Nephrol 12, 380–382 (2016). https://doi.org/10.1038/nrneph.2016.84

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