A new study reports an independent association between albuminuria and skin capillary rarefaction in a population-based cohort. These findings suggest that as well as reflecting injury to the glomeruli — a highly specialized microvascular bed — albuminuria might be a surrogate marker of systemic microvascular and endothelial dysfunction.
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References
Martens, R. J. et al. Capillary rarefaction associates with albuminuria: The Maastricht Study. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2015111219 (2016).
Stehouwer, C. D. & Smulders, Y. M. Microalbuminuria and risk for cardiovascular disease: analysis of potential mechanisms. J. Am. Soc. Nephrol. 17, 2106–2111 (2006).
Serne, E. H. et al. Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction. Hypertension 38, 238–242 (2001).
Clausen, P., Jensen, J. S., Jensen, G., Borch-Johnsen, K. & Feldt-Rasmussen, B. Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically healthy subjects. Circulation 103, 1869–1874 (2001).
Nannipieri, M. et al. Increased transcapillary escape rate of albumin in microalbuminuric type II diabetic patients. Diabetes Care 18, 1–9 (1995).
Nannipieri, M. et al. Transcapillary escape rate of albumin in type II diabetic patients. The relationship with microalbuminuria and hypertension. Diabetes Care 20, 1019–1026 (1997).
Ehling, J. et al. Quantitative micro-computed tomography imaging of vascular dysfunction in progressive kidney diseases. J. Am. Soc. Nephrol. 27, 520–532 (2016).
Triantafyllou, A. et al. Accumulation of microvascular target organ damage in newly diagnosed hypertensive patients. J. Am. Soc. Hypertens. 8, 542–549 (2014).
Rabelink, T. J. & de Zeeuw, D. The glycocalyx — linking albuminuria with renal and cardiovascular disease. Nat. Rev. Nephrol. 11, 667–676 (2015).
Acknowledgements
The author's work is supported by financial research grants of the German Research Foundation (DFG; SFB/TRR 57), by the German Federal Ministry of Education and Research (BMBF 01GM1518A) and by the Else-Kröner Fressenius Stiftung (EKFS 2012_A216).
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Boor, P. Albuminuria — a marker of systemic microvascular function. Nat Rev Nephrol 12, 449–450 (2016). https://doi.org/10.1038/nrneph.2016.82
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DOI: https://doi.org/10.1038/nrneph.2016.82
