Levels of FGF-23 increase early in the course of acute kidney injury (AKI) following cardiac surgery and are independently associated with severe AKI and adverse outcomes, say researchers. Among 250 patients undergoing cardiac surgery, those who developed AKI had significantly higher levels of plasma c-terminal FGF-23 at the end of cardiopulmonary bypass and on postoperative days 1 and 3. In those who developed severe AKI, the levels of intact FGF-23 also increased after surgery.
References
Leaf, D. E. et al. Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int. http://dx.doi.org/10.1016/j.kint.2015.12.035
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Carney, E. Postoperative FGF-23 levels are associated with AKI. Nat Rev Nephrol 12, 258 (2016). https://doi.org/10.1038/nrneph.2016.40
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DOI: https://doi.org/10.1038/nrneph.2016.40
