New data from the BENEFIT study demonstrate that belatacept improves long-term allograft and patient survival after kidney transplantation, despite higher rates of biopsy-proven acute rejection than with ciclosporin. The noninferiority design of BENEFIT represents a feasible strategy to further the development of innovator drugs to reduce late graft loss.
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Naesens, M., Thaunat, O. BENEFIT of belatacept: kidney transplantation moves forward. Nat Rev Nephrol 12, 261–262 (2016). https://doi.org/10.1038/nrneph.2016.34
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DOI: https://doi.org/10.1038/nrneph.2016.34