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BENEFIT of belatacept: kidney transplantation moves forward

Nature Reviews Nephrology volume 12, pages 261262 (2016) | Download Citation

New data from the BENEFIT study demonstrate that belatacept improves long-term allograft and patient survival after kidney transplantation, despite higher rates of biopsy-proven acute rejection than with ciclosporin. The noninferiority design of BENEFIT represents a feasible strategy to further the development of innovator drugs to reduce late graft loss.

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  1. 1.

    et al. Belatacept and long-term outcomes in kidney transplantation. N. Engl. J. Med. 374, 333–343 (2016).

  2. 2.

    , & Long-term renal allograft survival in the United States: a critical reappraisal. Am. J. Transplant. 11, 450–462 (2011).

  3. 3.

    et al. A phase III study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am. J. Transplant. 10, 535–546 (2010).

  4. 4.

    et al. A phase III study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). Am. J. Transplant. 10, 547–557 (2010).

  5. 5.

    , , , & Antibody-mediated rejection, T cell-mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies. Kidney Int. 85, 258–264 (2014).

  6. 6.

    et al. Long-term belatacept exposure maintains efficacy and safety at 5 years: results from the long-term extension of the BENEFIT study. Am. J. Transplant. 13, 2875–2883 (2013).

  7. 7.

    , , & Prevention of cardiovascular disease in adult recipients of kidney transplants. Lancet 378, 1419–1427 (2011).

  8. 8.

    , , , & Summary of the US FDA approval of belatacept. Am. J. Transplant. 12, 554–562 (2012).

  9. 9.

    & The elephant in the room: failings of current clinical endpoints in kidney transplantation. Am. J. Transplant. 10, 1163–1166 (2010).

  10. 10.

    et al. Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA 308, 2594–2604 (2012).

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Author information


  1. Department of Microbiology and Immunology, KU Leuven – University of Leuven, Herestraat 49, 3000 Leuven, Belgium.

    • Maarten Naesens
  2. Department of Transplantation, Nephrology and Clinical Immunology, Edouard Herriot Hospital, HCL, 5 Place d'Arsonval, 69003 Lyon, France.

    • Olivier Thaunat


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Competing interests

The authors declare no competing financial interests.

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Correspondence to Maarten Naesens.

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