Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Year in Review
  • Published:

Critical care nephrology in 2016

Managing organ dysfunction in critical care

Approaches to effectively prevent and manage organ dysfunction in critically ill patients remain elusive. Key studies in 2016 highlighted the challenges in finding effective treatments for renal failure in sepsis and assessed the optimal timing of renal replacement therapy initiation in critically ill patients with acute kidney injury.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Shankar-Hari, M. et al. Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315, 775–787 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Gordon, A. C. et al. Effect of early vasopressin versus norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial. JAMA 316, 509–518 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. Gordon, A. C. et al. Levosimendan for the prevention of acute organ dysfunction in sepsis. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1609409 (2016).

  4. Keh, D. et al. Effect of hydrocortisone on development of shock among patients with severe sepsis: the HYPRESS randomized clinical trial. JAMA 316, 1775–1785 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Graetz, T. J. & Hotchkiss, R. S. Sepsis: preventing organ failure in sepsis — the search continues. Nat. Rev. Nephrol. 13, 5–6 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Mehta, R. L. Renal-replacement therapy in the critically ill — does timing matter? N. Engl. J. Med. 375, 175–176 (2016).

    Article  PubMed  Google Scholar 

  7. Zarbock, A. et al. Effect of early versus delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA 315, 2190–2199 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Gaudry, S. et al. Initiation strategies for renal-replacement therapy in the intensive care unit. N. Engl. J. Med. 375, 122–133 (2016).

    Article  PubMed  Google Scholar 

  9. Barbar, S. D., Binquet, C., Monchi, M., Bruyere, R. & Quenot, J. P. Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial. Trials 15, 270 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Wald, R. et al. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int. 88, 897–904 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ravindra L. Mehta.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mehta, R. Managing organ dysfunction in critical care. Nat Rev Nephrol 13, 71–72 (2017). https://doi.org/10.1038/nrneph.2016.193

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2016.193

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing