Transplantation

Utilizing the transcriptome to predict allograft fibrosis

A new study has identified a gene set that might predict the development of renal allograft fibrosis. This finding represents a leap forward in transplant diagnostics, but further studies are needed to demonstrate that interventions based on this gene set can prevent fibrosis before it can be utilized to inform therapeutic decisions.

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Figure 1: Human renal allograft biopsy sample showing renal cortex with interstitial fibrosis and tubular atrophy.

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Correspondence to Adyr Moss.

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Moss, A., Kaplan, B. Utilizing the transcriptome to predict allograft fibrosis. Nat Rev Nephrol 12, 652–653 (2016). https://doi.org/10.1038/nrneph.2016.134

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