The traditional definition of sepsis requires the presence of at least two systemic inflammatory response syndrome (SIRS) criteria in addition to a suspected or proven infection. A recent large retrospective study, however, suggests that the requirement for two SIRS criteria excludes one in eight patients with severe sepsis.
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Acknowledgements
A.M.D. is supported by the Foundation for Anaesthesia Education and Research and the Washington University Institute of Clinical and Translational Sciences grant UL1 TR000448 from the National Center for Advancing Translational Sciences. R.S.H. is supported by NIH grants GM 44118 and GM 55194.
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R.S.H. has received grant support from MedImmune, Bristol–Myers Squibb, GlaxoSmithKline, Agennix and Aurigene. A.M.D. declares no competing interests.
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Drewry, A., Hotchkiss, R. Revising definitions of sepsis. Nat Rev Nephrol 11, 326–328 (2015). https://doi.org/10.1038/nrneph.2015.66
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DOI: https://doi.org/10.1038/nrneph.2015.66