Despite aggressive therapy, lupus nephritis (LN) remains an important predictor of morbidity in patients with systemic lupus erythematosus. Clinical trials of novel drugs have not improved LN outcomes; however, re-analysis of well-characterized cohorts has identified surrogate end points of long-term renal survival, which will facilitate testing and qualification of novel treatments.
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Rovin, B., Ayoub, I. MAINTAINing perspective in lupus nephritis trials. Nat Rev Nephrol 11, 389–390 (2015). https://doi.org/10.1038/nrneph.2015.65
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DOI: https://doi.org/10.1038/nrneph.2015.65
