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Renal fibrosis in 2015

Understanding the mechanisms of kidney fibrosis

Nature Reviews Nephrology volume 12, pages 68–70 (2016)Cite this article

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The year 2015 has seen great progress in the renal fibrosis field, as key studies began to build a consensus on the importance of epithelial-to-mesenchymal transition, cell cycle arrest, and defective metabolism in the pathogenesis of kidney fibrosis. New findings also point to a role of developmental signalling in renal fibrogenesis.

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Figure 1: Studies have highlighted important roles for varying tubular responses such as partial epithelial-to-mesenchymal transition (EMT), cell cycle arrest and defective metabolism in driving renal fibrosis.

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Acknowledgements

The author's work is supported by NIH grants DK064005, DK091239 and DK106049, and National Science of Foundation of China grants 81130011 and 81521003.

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Authors and Affiliations

  1. Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, 15261, Pennsylvania, USA

    Dong Zhou & Youhua Liu

  2. State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China

    Youhua Liu

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  1. Dong Zhou
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Correspondence to Youhua Liu.

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Zhou, D., Liu, Y. Understanding the mechanisms of kidney fibrosis. Nat Rev Nephrol 12, 68–70 (2016). https://doi.org/10.1038/nrneph.2015.215

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