2015 saw the publication of several important studies in the renal stem cell and developmental biology fields. Key studies provided insights into the ageing of nephron progenitors and optimal conditions to stimulate the expansion of nephron progenitors, and reported the in vitro generation of kidney organoids.
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References
Chen, S. et al. Intrinsic age-dependent changes and cell–cell contacts regulate nephron progenitor lifespan. Dev. Cell 35, 49–62 (2015).
Brown, A. C., Muthukrishnan, S. D. & Oxburgh, L. A synthetic niche for nephron progenitor cells. Dev. Cell 34, 229–241 (2015).
Barak, H., Huh, S., Chen, S. & Jeanpierre, C. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev. Cell 22, 1191–1207 (2012).
Taguchi, A. et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 14, 53–67 (2014).
Takasato, M. et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney. Nat. Cell Biol. 16, 118–126 (2014).
Takasato, M. et al. Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature 526, 564–568 (2015).
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Nishinakamura, R. Advances in generating and maintaining nephron progenitors. Nat Rev Nephrol 12, 67–68 (2016). https://doi.org/10.1038/nrneph.2015.203
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DOI: https://doi.org/10.1038/nrneph.2015.203