Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Acute kidney injury

Late-onset acute kidney injury—subacute or more of the same?

Fujii and colleagues define 'subacute' kidney injury (s-AKI) as AKI that takes >7 days to develop, timed from admission or lowest creatinine measurement after admission. Although s-AKI is unlikely to be a distinct syndrome from AKI, the association with increased mortality highlights the need to monitor patient creatinine levels.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chertow, G. M., Burdick, E., Honour, M., Bonventre, J. V. & Bates, D. W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 16, 3365–3370 (2005).

    Article  PubMed  Google Scholar 

  2. KDIGO. Clinical practice guideline for acute kidney injury. Section 2: AKI definition. Kidney Int. Suppl. 2, 19–36 (2012).

  3. Murray, P. T. et al. Current use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference. Kidney Int. http://dx.doi.org/10.1038/ki.2013.374.

  4. Haase, M. et al. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury a multicenter pooled analysis of prospective studies. J. Am. Coll. Cardiol. 57, 1752–1761 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Nickolas, T. L. et al. Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study. J. Am. Coll. Cardiol. 59, 246–255 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Nejat, M. et al. Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int. 81, 1254–1262 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Fujii, T., Uchino, S., Takinami, M. & Bellomo, R. Subacute kidney injury in hospitalized patients. Clin. J. Am. Soc. Nephrol. http://dx.doi.org/10.2215/CJN.04120413.

  8. Brown, J. R., Kramer, R. S., Coca, S. G. & Parikh, C. R. Duration of acute kidney injury impacts long-term survival after cardiac surgery. Ann. Thorac. Surg. 90, 1142–1148 (2010).

    Article  PubMed  Google Scholar 

  9. Endre, Z. H. et al. Differential diagnosis of AKI in clinical practice by functional and damage biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib. Nephrol. 182, 30–44 (2013).

    Article  PubMed  Google Scholar 

  10. Pickering, J. W. & Endre, Z. H. Back-calculating baseline creatinine with MDRD misclassifies acute kidney injury in the intensive care unit. Clin. J. Am. Soc. Nephrol. 5, 1165–1173 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zoltán H. Endre.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Endre, Z., Pickering, J. Late-onset acute kidney injury—subacute or more of the same?. Nat Rev Nephrol 10, 133–134 (2014). https://doi.org/10.1038/nrneph.2014.9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2014.9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing