Hypotonic fluid administration has been the standard of care for maintenance fluid therapy in acutely ill children, but this approach is associated with hospital-acquired hyponatraemia and hyponatraemic encephalopathy. New findings demonstrate that isotonic maintenance fluids are safe and effective in preventing hospital-acquired hyponatraemia in children, whereas a 0.45% NaCl solution is not.
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M.L.M and J.C.A have received consulting fees from Otsuka Pharmaceuticals.
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Moritz, M., Ayus, J. Isotonic fluids prevent hospital-acquired hyponatraemia. Nat Rev Nephrol 11, 202–203 (2015). https://doi.org/10.1038/nrneph.2014.253
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DOI: https://doi.org/10.1038/nrneph.2014.253
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