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Polycystic kidney disease

HALTing PKD progression—revival of blood pressure control

New research suggests that rigorous blood pressure control is beneficial in early autosomal dominant polycystic kidney disease (ADPKD). Although a positive effect on the rate of decline of estimated glomerular filtration rate remains to be demonstrated, this study is likely to change current treatment strategies for young patients with ADPKD.

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References

  1. Kurschat, C. E. et al. An approach to cystic kidney diseases: the clinician's view. Nat. Rev. Nephrol. 10, 687–699 (2014).

    Article  CAS  PubMed  Google Scholar 

  2. Spithoven, E. M. et al. Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival—an analysis of data from the ERA-EDTA Registry. Nephrol. Dial. Transplant. 29 (Suppl. 4), 15–25 (2014).

    Article  Google Scholar 

  3. Schrier, R. W. et al. Predictors of autosomal dominant polycystic kidney disease progression. J. Am. Soc. Nephrol. 25, 2399–2418 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Schrier, R. W. et al. Blood Pressure in early autosomal dominant polycystic kidney disease. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1402685.

  5. Torres, V. E. et al. Angiotensin blockade in late autosomal dominant polycystic kidney disease. N. Engl. J. Med. http://dx.doi.org/10.1056/NEJMoa1402686.

  6. Chapman, A. B. et al. The HALT polycystic kidney disease trials: design and implementation. Clin. J. Am. Soc. Nephrol. 5, 102–109 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Cornec-Le Gall, E. & Le Meur, Y. Polycystic kidney disease: Kidney volume—a crystal ball for ADPKD prognosis? Nat. Rev. Nephrol. 10, 485–486 (2014).

    Article  PubMed  Google Scholar 

  8. Walz, G. et al. Everolimus in patients with autosomal dominant polycystic kidney disease. N. Engl. J. Med. 363, 830–840 (2010).

    Article  CAS  PubMed  Google Scholar 

  9. Serra, A. L. et al. Sirolimus and kidney growth in autosomal dominant polycystic kidney disease. N. Engl. J. Med. 363, 820–829 (2010).

    Article  CAS  PubMed  Google Scholar 

  10. Torres, V. E. et al. Tolvaptan in patients with autosomal dominant polycystic kidney disease. N. Engl. J. Med. 367, 2407–2418 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

T.B. is supported by the German Research Foundation (BE2212 and SFB829, SFB832, SFB635). The author apologizes to those whose work could not be cited due to space limitations.

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Correspondence to Thomas Benzing.

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T.B. receives speaker honoraria from Hexal, Novartis and Otsuka.

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Benzing, T. HALTing PKD progression—revival of blood pressure control. Nat Rev Nephrol 11, 129–131 (2015). https://doi.org/10.1038/nrneph.2014.241

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