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Transplantation

Molecular phenotyping of T-cell-mediated rejection

Nature Reviews Nephrology volume 10, pages 678–680 (2014)Cite this article

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A new study has reported a molecular signature of T-cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-γ and macrophages. Inhibitors of T-cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.

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Figure 1: TCMR gene expression analysis suggests a model of TCMR in which effector CD4+ T cells engage in cognate interactions with DCs and possibly B cells, facilitating their differentiation into TH1 cells, which secrete IFN-γ to promote DC maturation, macrophage recruitment and CD8+ T-effector-cell differentiation.

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Acknowledgements

The work of A.S.C. is supported in part by grants from NIAID and NIH (R01AI110513 and P01AI097113).

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Authors and Affiliations

  1. Department of Surgery, University of Chicago, 5841 South Maryland Avenue, Chicago, 60637, IL, USA

    Anita S. Chong

  2. Department of Surgery, University of Illinois, 909 South Wolcott Avenue, Chicago, 60612, IL, USA

    David L. Perkins

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  1. Anita S. Chong
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Correspondence to Anita S. Chong.

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Chong, A., Perkins, D. Molecular phenotyping of T-cell-mediated rejection. Nat Rev Nephrol 10, 678–680 (2014). https://doi.org/10.1038/nrneph.2014.197

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