A new study suggests that use of unadjusted dosages of β-lactam antibiotics could reduce the risk of inadequate serum concentrations during continuous renal replacement therapy. However, risk of overdose compounds the problem. Therapeutic drug monitoring, pharmacokinetic modelling and dose simulation might provide opportunities to improve dose precision and patient outcomes.
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Chow, K., Li, PT. Antibiotic therapy during CRRT—getting the dose just right. Nat Rev Nephrol 10, 486–488 (2014). https://doi.org/10.1038/nrneph.2014.136
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DOI: https://doi.org/10.1038/nrneph.2014.136
