Acute or chronic antibody-mediated rejection (ABMR) of kidney allografts is currently diagnosed by the presence of donor-specific alloantibodies and distinct pathological findings in biopsy samples. A new study highlights the potential of molecular diagnostics incorporated into standard criteria for acute ABMR to help identify patients at risk of graft loss.
Subscribe to Journal
Get full journal access for 1 year
only $17.42 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Loupy, A. et al. Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2013111149.
Hidalgo, L. G. et al. De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure. Am. J. Transplant. 9, 2532–2541 (2009).
Haas, M. et al. Banff meeting report: inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am. J. Transplant. 14, 272–283 (2013).
Sis, B. et al. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am. J. Transplant. 9, 2312–2323 (2009).
Hidalgo, L. G. et al. NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am. J. Transplant. 10, 1812–1822 (2010).
Sellares, J. et al. Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Am. J. Transplant. 13, 971–983 (2013).
Halloran, P. F. et al. Microarray diagnosis of antibody-mediated rejection in kidney transplant biopsies: an international prospective study (INTERCOM). Am. J. Transplant. 13, 2865–2874 (2013).
Volk, H. D., Sawitzki, B. & Reinke, P. Molecular analysis of renal allograft biopsies—more than a nice toy for researchers? Am. J. Transplant. 13, 539–540 (2013).
Sinn, P. et al. Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility [German]. Geburtshilfe Frauenheilkd. 73, 932–940 (2013).
The authors thank Dr Geraldine Rauch at the Institute of Medical Biostatics and Professor Burkhard Tönshoff at the University Children's Hospital, University of Heidelberg, Germany, for helpful discussions.
The authors declare no competing financial interests.
About this article
Cite this article
Morath, C., Zeier, M. Molecular diagnosis of kidney transplant rejection. Nat Rev Nephrol 10, 429–430 (2014). https://doi.org/10.1038/nrneph.2014.106
An update on chemical pharmacotherapy options for the prevention of kidney transplant rejection with a focus on costimulation blockade
Expert Opinion on Pharmacotherapy (2017)