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Molecular diagnosis of kidney transplant rejection

Acute or chronic antibody-mediated rejection (ABMR) of kidney allografts is currently diagnosed by the presence of donor-specific alloantibodies and distinct pathological findings in biopsy samples. A new study highlights the potential of molecular diagnostics incorporated into standard criteria for acute ABMR to help identify patients at risk of graft loss.

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  1. 1

    Loupy, A. et al. Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection. J. Am. Soc. Nephrol.

  2. 2

    Hidalgo, L. G. et al. De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure. Am. J. Transplant. 9, 2532–2541 (2009).

    CAS  Article  Google Scholar 

  3. 3

    Haas, M. et al. Banff meeting report: inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am. J. Transplant. 14, 272–283 (2013).

    Article  Google Scholar 

  4. 4

    Sis, B. et al. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am. J. Transplant. 9, 2312–2323 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Hidalgo, L. G. et al. NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am. J. Transplant. 10, 1812–1822 (2010).

    CAS  Article  Google Scholar 

  6. 6

    Sellares, J. et al. Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Am. J. Transplant. 13, 971–983 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Halloran, P. F. et al. Microarray diagnosis of antibody-mediated rejection in kidney transplant biopsies: an international prospective study (INTERCOM). Am. J. Transplant. 13, 2865–2874 (2013).

    CAS  Article  Google Scholar 

  8. 8

    Volk, H. D., Sawitzki, B. & Reinke, P. Molecular analysis of renal allograft biopsies—more than a nice toy for researchers? Am. J. Transplant. 13, 539–540 (2013).

    CAS  Article  Google Scholar 

  9. 9

    Sinn, P. et al. Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility [German]. Geburtshilfe Frauenheilkd. 73, 932–940 (2013).

    CAS  Article  Google Scholar 

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The authors thank Dr Geraldine Rauch at the Institute of Medical Biostatics and Professor Burkhard Tönshoff at the University Children's Hospital, University of Heidelberg, Germany, for helpful discussions.

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Correspondence to Martin Zeier.

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The authors declare no competing financial interests.

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Morath, C., Zeier, M. Molecular diagnosis of kidney transplant rejection. Nat Rev Nephrol 10, 429–430 (2014).

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