Acute or chronic antibody-mediated rejection (ABMR) of kidney allografts is currently diagnosed by the presence of donor-specific alloantibodies and distinct pathological findings in biopsy samples. A new study highlights the potential of molecular diagnostics incorporated into standard criteria for acute ABMR to help identify patients at risk of graft loss.
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Acknowledgements
The authors thank Dr Geraldine Rauch at the Institute of Medical Biostatics and Professor Burkhard Tönshoff at the University Children's Hospital, University of Heidelberg, Germany, for helpful discussions.
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Morath, C., Zeier, M. Molecular diagnosis of kidney transplant rejection. Nat Rev Nephrol 10, 429–430 (2014). https://doi.org/10.1038/nrneph.2014.106
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Further reading
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An update on chemical pharmacotherapy options for the prevention of kidney transplant rejection with a focus on costimulation blockade
Expert Opinion on Pharmacotherapy (2017)
