Mutations in the genes that encode polycystin-1 and polycystin-2 are the principal cause of autosomal dominant polycystic kidney disease. These proteins form a receptor–ion-channel complex and were thought to regulate tubule luminal diameter in a codependent manner. However, new data suggest a more antagonistic relationship between the proteins.
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Acknowledgements
The authors' research is supported by the Intramural program of the National Institute of Diabetes and Digestive and Kidney Diseases (ZIA DK075042; G. G. Germino) and by NIH grants P30DK090868 and DK095036 (T. J. Watnick).
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Watnick, T., Germino, G. Polycystin-1 and polycystin-2—it's complicated. Nat Rev Nephrol 9, 249–250 (2013). https://doi.org/10.1038/nrneph.2013.73
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DOI: https://doi.org/10.1038/nrneph.2013.73
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