Use of angiotensin-converting enzyme (ACE) inhibitors as first-line antihypertensives in patients with diabetes mellitus is supported by data from a new meta-analysis. Compared with placebo, ACE inhibitors significantly reduced doubling of serum creatinine levels and β-blockers significantly increased mortality in these patients (n = 36,917). Angiotensin-receptor blockers, calcium channel blockers, diuretics and combination therapies had no significant effects on these outcomes and none of the therapies had a significant effect on dialysis requirement in the study participants.
References
Wu, H.-Y. et al. Comparative effectiveness of renin–angiotensin system blockers and other antihypertensive drugs in patients with diabetes: systematic review and bayesian network meta-analysis. BMJ 10.1136/bmj.f6008
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Effectiveness of antihypertensives in patients with diabetes. Nat Rev Nephrol 10, 2 (2014). https://doi.org/10.1038/nrneph.2013.240
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DOI: https://doi.org/10.1038/nrneph.2013.240