The risk of bone fracture is increased in patients with chronic kidney disease (CKD), but current treatments to reduce fractures might be associated with an increased risk of arterial calcification. Both calcium and zoledronic acid treatment, alone or in combination, improved bone volume and suppressed bone remodelling in a rat model of CKD. Improvements in the biomechanical properties of bone and a reduced parathyroid hormone level were seen with calcium treatment alone, but at increased risk of extra-skeletal calcification.
ORIGINAL RESEARCH PAPER
Moe, S. M. et al. A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD. J. Bone Miner. Res. doi:10.1002/jbmr.2089
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Calcium and zoledronic acid increase bone volume in CKD. Nat Rev Nephrol 9, 626 (2013). https://doi.org/10.1038/nrneph.2013.186
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DOI: https://doi.org/10.1038/nrneph.2013.186