A post hoc analysis of data from the RENAAL and IDNT trials shows that a low-sodium diet can increase the efficacy of angiotensin-receptor blockers (ARBs) in patients with type 2 diabetic nephropathy. A comparison of the treatment effects of ARBs and non-renin–angiotensin–aldosterone-system (RAAS)-based antihypertensive therapy in subgroups based on sodium intake showed that the treatment effects of ARBs versus non-RAAS-based therapies on cardiovascular and renal end points were greater in patients with lower versus higher sodium intake.
ORIGINAL RESEARCH PAPER
Heerspink, H. J. et al. Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers. Kidney Int. doi:10.1038/ki.2012.74
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Dietary sodium restriction can improve ARB effectiveness. Nat Rev Nephrol 8, 253 (2012). https://doi.org/10.1038/nrneph.2012.53
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DOI: https://doi.org/10.1038/nrneph.2012.53