Conversion from ciclosporin to everolimus 4.5 months after transplantation can lead to improvements in renal function that are maintained for 3 years. These are the long-term results of the ZEUS study, which included 300 renal transplant recipients randomized to either continuing on ciclosporin or converting to everolimus after 4.5 months. At 3 years, mean estimated glomerular filtration rate was significantly higher in patients in the everolimus group than in the ciclosporin group. Although the incidence of biopsy-proven acute rejection was greater in the everolimus group, patient and graft survival were similar in the two groups.
ORIGINAL RESEARCH PAPER
Budde, K. et al. Conversion from cyclosporine to everolimus at 4.5 months posttransplant: 3-year results from the randomized ZEUS study. Am. J. Transplant. doi:10.1111/j.1600-6143.2012.03994.x
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Conversion to everolimus might improve renal function. Nat Rev Nephrol 8, 252 (2012). https://doi.org/10.1038/nrneph.2012.47
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DOI: https://doi.org/10.1038/nrneph.2012.47