Individuals with HIV disease frequently experience kidney dysfunction, which is accompanied by an increased risk of cardiovascular disease and death. Choi et al. have found that albuminuria and an estimated glomerular filtration rate of <60 ml/min/1.73 m2, estimated using serum cystatin C level, accounted for 17% of the population-attributable 5-year mortality risk in a cohort of patients with HIV infection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Crum, N. F. et al. Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras. J. Acquir. Immune Defic. Syndr. 41, 194–200 (2006).
Neuhaus, J. et al. Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J. Infect. Dis. 201, 1788–1795 (2010).
Lundgren, J. D. et al. Biomarkers in HIV disease. Curr. Opin. HIV AIDS 5, 459–462 (2010).
Choi, A. et al. Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected persons. Am. J. Kidney Dis. 56, 872–882 (2010).
Djoussé, L., Kurth, T. & Gaziano, J. M. Cystatin C and risk of heart failure in the Physicians' Health Study (PHS). Am. Heart J. 155, 82–86 (2008).
Rifkin, D. E. et al. Albuminuria, impaired kidney function and cardiovascular outcomes or mortality in the elderly. Nephrol. Dial. Transplant. 25, 1560–1567 (2010).
Peralta, C. A. et al. Cystatin C identifies chronic kidney disease patients at higher risk for complications. J. Am. Soc. Nephrol. 22, 147–155 (2011).
Szczech, L. A. et al. Association between renal disease and outcomes among HIV-infected women receiving or not receiving antiretroviral therapy. Clin. Infect. Dis. 39, 1199–1206 (2004).
Wyatt, C. M. et al. Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. J. Acquir. Immune Defic. Syndr. 55, 73–77 (2010).
Choi, A. I. et al. Association between kidney function and albuminuria with cardiovascular events in HIV-infected persons. Circulation 121, 651–658 (2010).
Acknowledgements
The author's work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases.
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Kopp, J. Kidney markers predict mortality in patients with HIV disease. Nat Rev Nephrol 7, 186–188 (2011). https://doi.org/10.1038/nrneph.2011.27
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2011.27