Interleukin 6 (IL-6) has an important role in angiotensin (Ang)-II-induced hypertension and chronic kidney disease (CKD), say researchers. Zhang et al. found that expression of IL-6 was increased in kidneys of patients with CKD and even further increased in kidneys of patients with CKD and hypertension. Ang II caused IL-6 induction in mouse kidneys and genetic deletion of IL-6 led to reduced hypertension and a decrease in renal injury in Ang-II-infused mice.
ORIGINAL RESEARCH PAPER
Zhang, W. et al. Interleukin 6 underlies angiotensin II–induced hypertension and chronic renal damage. Hypertension doi:10.1161/HYPERTENSIONAHA.111.173328
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IL-6 involvement in hypertension and renal disease. Nat Rev Nephrol 8, 3 (2012). https://doi.org/10.1038/nrneph.2011.185
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DOI: https://doi.org/10.1038/nrneph.2011.185
