Endothelial dysfunction in cardiovascular disease is associated with an increase in circulating levels of endothelial microparticles (EMPs). Amabile et al. assessed EMP levels in 81 patients on hemodialysis with the use of flow cytometry and found that EMP levels could be used to identify asymptomatic patients who are at risk of developing cardiovascular disease. Together with older age, EMP levels were found to be an independent predictor of all-cause and cardiovascular mortality.