Further research is needed into the association of hyperuricemia with cardiovascular risk in patients on hemodialysis following results from a study by Latif et al. indicating that increased uric acid levels are associated with a decreased risk of all-cause and cardiovascular mortality in this population. This finding is the opposite to that seen in the general population. The authors speculate that hyperuricemia is a surrogate for better nutritional status, but as the association persisted after adjustment for higher BMI, protein intake, and serum creatinine level, other mechanisms may be involved.
ORIGINAL RESEARCH PAPER
Latif, W. et al. Uric acid levels and all-cause and cardiovascular mortality in the hemodialysis population. Clin. J. Am. Soc. Nephrol. doi:10.2215/CJN.00670111
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Hyperuricemia and cardiovascular mortality in patients on hemodialysis. Nat Rev Nephrol 7, 606 (2011). https://doi.org/10.1038/nrneph.2011.142
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DOI: https://doi.org/10.1038/nrneph.2011.142