Further research is needed into the association of hyperuricemia with cardiovascular risk in patients on hemodialysis following results from a study by Latif et al. indicating that increased uric acid levels are associated with a decreased risk of all-cause and cardiovascular mortality in this population. This finding is the opposite to that seen in the general population. The authors speculate that hyperuricemia is a surrogate for better nutritional status, but as the association persisted after adjustment for higher BMI, protein intake, and serum creatinine level, other mechanisms may be involved.