Researchers in Belgium report that histone deacetylase inhibitors might be beneficial in chronic kidney disease. Using a mouse model of glomerulosclerosis, Van Beneden and co-workers showed that administration of valproic acid before kidney injury prevented proteinuria and kidney disease; when administered after proteinuria was established, valproic acid decreased proteinuria and limited progression of renal disease.
ORIGINAL RESEARCH PAPER
Van Beneden, K. et al. Valproic acid attenuates proteinuria and kidney injury. J. Am. Soc. Nephrol. doi:10.1681/ASN.2010111196
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Histone deacetylase inhibitors may be useful in chronic kidney disease. Nat Rev Nephrol 7, 606 (2011). https://doi.org/10.1038/nrneph.2011.129
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DOI: https://doi.org/10.1038/nrneph.2011.129