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Diabetic nephropathy

Diabetic nephropathy—challenges in pathologic classification

Nature Reviews Nephrology volume 6, pages 508–510 (2010)Cite this article

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A new pathologic classification scheme for diabetic nephropathy, in which only glomerular lesions are used to classify renal damage associated with either type 1 or type 2 diabetes, has been developed in association with the Renal Pathology Society. Given the heterogeneity of the renal lesions underlying diabetic nephropathy and the complex natural history of the disease, this scheme is not yet ready for clinical application but should be considered an important first step towards the development of a clinically useful classification system.

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References

  1. Tervaert, T. W. et al. Pathologic classification of diabetic nephropathy. J. Am. Soc. Nephrol. 21, 556–563 (2010).

    Article  Google Scholar 

  2. Parving, H.-H., Mauer, M. & Ritz, E. In Brenner & Rector's The Kidney, 7th edn (ed. Brenner, B. M). 1777–1818 (Saunders, Philadelphia, 2004).

    Google Scholar 

  3. Fioretto, P., Caramori, M. L. & Mauer, M. The kidney in diabetes: dynamic pathways of injury and repair. Diabetologia 51, 1347–1355 (2008).

    Article  CAS  Google Scholar 

  4. Osterby, R. et al. Glomerular structure and function in proteinuric type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36, 1064–1070 (1993).

    Article  CAS  Google Scholar 

  5. Fioretto, P. et al. Patterns of renal injury in NIDDM patients with microalbuminuria. Diabetologia 39, 1569–1576 (1996).

    Article  CAS  Google Scholar 

  6. Gambara, V., Mecca, G., Remuzzi, G. & Bertani, T. Heterogeneous nature of renal lesions in type II diabetes. J. Am. Soc. Nephrol. 3, 1458–1466 (1993).

    CAS  PubMed  Google Scholar 

  7. Mauer, S. M. et al. Structural–functional relationships in diabetic nephropathy. J. Clin. Invest. 74, 1143–1155 (1984).

    Article  CAS  Google Scholar 

  8. Urizar, R. E, Schwartz, A., Top F. Jr & Vernier, R. L. The nephrotic syndrome in children with diabetes mellitus of recent onset. N. Engl. J. Med. 281, 173–181 (1969).

    Article  CAS  Google Scholar 

  9. Najafian, B., Crosson, J. T., Kim, Y. & Mauer, M. Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes. J. Am. Soc. Nephrol. 17 (Suppl. 2), S53–S60 (2006).

    Article  Google Scholar 

  10. Harris, R. D., Steffes, M. W., Bilous, R. W., Sutherland, D. E. & Mauer, S. M. Global glomerular sclerosis and glomerular arteriolar hyalinosis in insulin dependent diabetes. Kidney Int. 40, 107–114 (1991).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy

    Paola Fioretto

  2. Departments of Pediatrics and Medicine, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 491, Minneapolis, 55455, MN, USA

    Michael Mauer

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  1. Paola Fioretto
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  2. Michael Mauer
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Correspondence to Paola Fioretto.

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Fioretto, P., Mauer, M. Diabetic nephropathy—challenges in pathologic classification. Nat Rev Nephrol 6, 508–510 (2010). https://doi.org/10.1038/nrneph.2010.96

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