Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Transplantation

Can a single criterion determine the use of ECD kidneys?

Increased use of kidneys from expanded-criteria donors (ECDs) for both single and dual kidney transplantation has led to controversy over the criteria for selecting appropriate organs. Although several selection criteria have been proposed to determine the 'transplantability' of ECD kidneys, comprehensive clinical and histological assessment before transplantation remains necessary.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Lee, C. M. et al. The kidneys that nobody wanted: support for the utilization of expanded criteria donors. Transplantation 62, 1832–1841 (1996).

    Article  CAS  Google Scholar 

  2. Snanoudj, R. et al. Donor-estimated GFR as an appropriate criterion for allocation of ECD kidneys into single or dual kidney transplantation. Am. J. Transplant. 9, 2542–2551 (2009).

    Article  CAS  Google Scholar 

  3. Remuzzi, G. et al. Long-term outcome of renal transplantation from older donors. N. Engl. J. Med. 354, 343–352 (2006).

    Article  CAS  Google Scholar 

  4. Rigotti, P. et al. Outcomes of renal transplantation from very old donors. N. Engl. J. Med. 360, 1464–1465 (2009).

    Article  CAS  Google Scholar 

  5. Moore, J. et al. Identification of the optimal donor quality scoring system and measure of early renal function in kidney transplantation. Transplantation 87, 578–586 (2009).

    Article  Google Scholar 

  6. Schold, J. D., Kaplan, B., Baliga, R. S. & Meier-Kriesche, H. U. The broad spectrum of quality in deceased donor kidneys. Am. J. Transplant. 5, 757–765 (2005).

    Article  Google Scholar 

  7. Andrés, A. et al. Double versus single renal allografts from aged donors. Transplantation 69, 2060–2066 (2000).

    Article  Google Scholar 

  8. Gill, J. et al. Outcomes of dual kidney transplantation in the United States: an analysis of the OPTN/UNOS database. Transplantation 85, 62–68 (2008).

    Article  Google Scholar 

  9. Ekser, B. et al. Monolateral placement of both kidneys in dual kidney transplantation: low surgical complication rate and short operating time. Transpl. Int. 19, 485–491 (2006).

    Article  Google Scholar 

  10. Pascual, J., Zamora, J. & Pirsch, J. D. A systematic review of kidney transplantation from expanded criteria donors. Am. J. Kidney Dis. 52, 553–586 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paolo Rigotti.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ekser, B., Rigotti, P. Can a single criterion determine the use of ECD kidneys?. Nat Rev Nephrol 6, 68–70 (2010). https://doi.org/10.1038/nrneph.2009.226

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2009.226

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing