Yan et al. report that the neurotransmitter dopamine can prevent the activation of the NOD-, LRR- and pyrin domain-containing 3 (NLRP3) inflammasome. Signalling through the dopamine D1 receptor (DRD1) stimulated the production of cyclic AMP, which bound to NLRP3 and promoted its ubiquitylation and subsequent degradation. Notably, dopamine and DRD1 signalling suppressed NLRP3 inflammasome activation in models of neurotoxin-induced inflammation, lipopolysaccharide-induced systemic inflammation and monosodium urate-induced peritonitis. These findings suggest an important anti-inflammatory role for dopamine.
References
Yan, Y. et al. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell http://dx.doi.org/10.1016/j.cell.2014.11.047 (2014)
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Bordon, Y. Dopamine blocks inflammasome activation. Nat Rev Immunol 15, 69 (2015). https://doi.org/10.1038/nri3817
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DOI: https://doi.org/10.1038/nri3817
