Group 2 innate lymphoid cells (ILCs) that have previously been detected in the gut, lungs and adipose tissue express CD25 and interleukin-33 receptor (IL-33R) and produce IL-5 and IL-13 following stimulation. Here, Kim et al. characterize group 2 ILCs in the skin. LIN−CD25+IL-33R+ group 2 ILCs were detected in healthy human skin, and their numbers were increased in skin lesions from patients with atopic dermatitis. Moreover, group 2 ILCs producing IL-5 and IL-13 were enriched in the skin of mice with atopic dermatitis-like disease and promoted disease pathogenesis in these mice. Unlike group 2 ILCs at other anatomic locations, cutaneous group 2 ILCs did not require IL-25 and IL-33 signalling for their pathogenic function but instead depended on thymic stromal lymphopoietin, the levels of which are known to be increased in patients with atopic dermatitis.
ORIGINAL RESEARCH PAPER
Kim, B. S. et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci. Transl. Med. 30 Jan 2013 (doi:10.1126/scitranslmed.3005374)
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Papatriantafyllou, M. Group 2 ILCs in the skin. Nat Rev Immunol 13, 155 (2013). https://doi.org/10.1038/nri3419
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DOI: https://doi.org/10.1038/nri3419
