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Lymphocyte development

PAXIP1 — a gatekeeper of thymocyte development

Nature Reviews Immunology volume 13, pages 2–3 (2013)Cite this article

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PAXIP1 ... regulates the accessibility of the TCR α-chain (Tcra) locus for recombination and links genomic integrity with thymocyte egress

Opening of the chromatin structure during germline transcription enables the binding of recombination activating gene (RAG) proteins to recombination signal sequences at the variable (V), diversity (D) and joining (J) segments of the TCR loci. It has been proposed that H3K4me3 marks (which are generated through the trimethylation of histone H3 at lysine 4) recruit RAG proteins and promote the formation of double-strand breaks (DSBs) prior to recombination.

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References

ORIGINAL RESEARCH PAPER

  1. Callen, E. et al. The DNA damage- and transcription-associated protein Paxip1 controls thymocyte development and emigration. Immunity 15 Nov 2012 (doi:10.1016/j.immuni.2012.10.007)

FURTHER READING

  1. Schatz, D. G. Recombination centres and the orchestration of V(D)J recombination. Nature Rev. Immunol. 11, 251–263 (2011)

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Authors
  1. Maria Papatriantafyllou
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Papatriantafyllou, M. PAXIP1 — a gatekeeper of thymocyte development. Nat Rev Immunol 13, 2–3 (2013). https://doi.org/10.1038/nri3367

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