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Innate immunity

Inflammasome triggered by cell swelling

Nature Reviews Immunology volume 12, pages 742–743 (2012)Cite this article

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These data support the use of hypertonic solutions to treat inflammatory diseases

Several stress-associated stimuli induce the oligomerization of NLRP3 molecules and the formation of active inflammasomes, which cleave pro-caspase 1 and thereby promote caspase 1-mediated maturation of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Cell swelling in the presence of a hypotonic solution, or as a result of water influx following the intracellular accumulation of uric acid crystals, has been previously shown to induce the maturation of IL-1β in macrophages. So, Compan et al. set out to characterize the molecular events that lead to cell volume-dependent IL-1β processing.

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ORIGINAL RESEARCH PAPER

  1. Compan, V. et al. Cell volume regulation modulates NLRP3 inflammasome activation. Immunity 37, 487–500 (2012)

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  1. Maria Papatriantafyllou
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Papatriantafyllou, M. Inflammasome triggered by cell swelling. Nat Rev Immunol 12, 742–743 (2012). https://doi.org/10.1038/nri3324

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