Labelling antigen-specific T cells with peptide–MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.
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We would like to thank our sources of funding for this work. M.M.D. is supported by the Howard Hughes Medical Institute, the Bill and Melinda Gates Foundation (51731) and grants from the US National Institutes of Health (NIH; U19AI057229). J.D.A. is supported by NIH grants to the NIH Tetramer Core Facility (N01A125456M0D13) and the Emory Center for AIDS research (P30 AI050409). E.W.N. is supported by a Steven and Edward Bielfelt Postdoctoral Fellowship from the American Cancer Society.
Mark M. Davis and John D. Altman hold a patent for use of peptide–MHC tetramers and receive royalties for their commercial use.
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PLOS Biology (2019)
The Journal of Immunology (2019)
Cancer Immunology, Immunotherapy (2019)
Current Protocols in Immunology (2019)
European Journal of Immunology (2018)