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For those wanting more on the chemistry and biology of the cannabinoid system, this is a recent and authoritative review.
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Cannabinoids are best known for their psychoactive effects on the brain. This Review, together with references 28 and 29, discusses these mechanisms in detail.
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The many putative roles of cannabinoid receptors in immune-cell biology remain undefined. This paper indicates that these receptors might have a role in leukaemia.
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This report was among the first to show that cannabinoid-receptor expression changes with variations in immune-cell activation.
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Using an animal model of closed head injury, this paper shows that non-psychoactive cannabinoids can suppress the production of pro-inflammatory cytokines.
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This was the first report to show that cannabinoids bias the immune response away from TH1-cell responses.
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This report provided the first evidence from a human study to support the findings in animals that indicate that marijuana-derived cannabinoids bias TH-cell responses.
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The central effects of cannabinoids that bind CB1 might have a role in controlling spasticity and tremor in individuals with multiple sclerosis, as shown in animals with chronic, relapsing EAE.
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In this paper, a novel mechanism is reported for endocannabinoids in the inhibition of tumour growth.
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This study shows that cannabinoids might inhibit pain by binding CB2, as well as CB1.
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The endocannabinoid system might control and regulate intestinal inflammatory responses, as reported in this paper.
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References 112–114 use animal models to show the anti-inflammatory potential of non-psychoactive cannabinoids.
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This paper indicates that there might be more than two cannabinoid receptors.
Biswas, K. K. et al. Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. Hepatology 38, 1167–1177 (2003).
This paper shows that lipid rafts might be affected by cannabinoid-based drugs.
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