T cells

Successful checkpoint blockade requires positive co-stimulation

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References

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    Kamphorst, A. O. et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science http://dx.doi.org/10.1126/science.aaf0683 (2017)

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    Hui, E. et al. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science http://dx.doi.org/10.1126/science.aaf1292 (2017)

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Flemming, A. Successful checkpoint blockade requires positive co-stimulation. Nat Rev Immunol 17, 215 (2017) doi:10.1038/nri.2017.32

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