Monocytes and tissue macrophages represent two main branches of the mononuclear phagocyte system, and they have complementary roles during immunological challenges. Several studies published in 2017 highlighted the distinct properties of these two cell types and furthered our understanding of their development and cellular functions.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
Cancer Nanotechnology Open Access 17 April 2023
-
Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1
Nature Communications Open Access 03 January 2023
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pirzgalska, R. M. et al. Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nat. Med. 23, 1309–1318 (2017).
Camell, C. D. et al. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 550, 119–123 (2017).
Nguyen, K. D. et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480, 104–108 (2011).
Fischer, K. et al. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat. Med. 23, 623–630 (2017).
Wolf, Y. et al. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat. Immunol. 137, 495 (2017).
Mildner, A. et al. Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C- cells. Immunity 46, 849–862.e7 (2017).
Patel, A. A. et al. The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. J. Exp. Med. 214, 1913–1923 (2017).
Thomas, G. D. et al. Deleting an Nr4a1 super-enhancer subdomain ablates Ly6Clow monocytes while preserving macrophage gene function. Immunity 45, 975–987 (2016).
Askenase, M. H. et al. Bone-marrow-resident NK cells prime monocytes for regulatory function during infection. Immunity 42, 1130–1142 (2015).
Yáñez, A. et al. Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes. Immunity 47, 890–902.e4 (2017).
Acknowledgements
SJ is supported by the European Research Council (340345) and the Israel Science Foundation.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Jung, S. Macrophages and monocytes: of tortoises and hares. Nat Rev Immunol 18, 85–86 (2018). https://doi.org/10.1038/nri.2017.158
Published:
Issue Date:
DOI: https://doi.org/10.1038/nri.2017.158
This article is cited by
-
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development
Cancer Nanotechnology (2023)
-
Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1
Nature Communications (2023)
-
Pathogenic stromal cells as therapeutic targets in joint inflammation
Nature Reviews Rheumatology (2018)
