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Characterizing the US FDA's approach to promoting transformative innovation

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Figure 1: Characteristics of novel therapeutics approved by the FDA between 2005 and 2012, stratified by degree of innovation.

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Correspondence to Joseph S. Ross.

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H. Krumholz and J. Ross are funded by research agreements through Yale University from Medtronic and Johnson & Johnson (Janssen) to develop methods of clinical trial data sharing, by the US Centers for Medicare & Medicaid Services to develop and maintain performance measures, and by the US Food and Drug Administration to develop methods for post-market surveillance of medical devices. H. Krumholz chairs a cardiac scientific advisory board for UnitedHealth. The other authors do not have competing interests to report.

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This research was not supported by any external grants or funds.

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Data and analysis (PDF 449 kb)

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Novel therapeutics approved by the FDA between 2005 and 2012 and their degree of innovation, stratified by drug type and therapeutic area. (PDF 113 kb)

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Downing, N., Krumholz, H., Ross, J. et al. Characterizing the US FDA's approach to promoting transformative innovation. Nat Rev Drug Discov 14, 740–741 (2015).

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