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The International Serious Adverse Events Consortium

Nature Reviews Drug Discovery volume 13, pages 795796 (2014) | Download Citation

The International Serious Adverse Events Consortium is generating novel insights into the genetics and biology of drug-induced serious adverse events, and thereby improving pharmaceutical product development and decision-making.

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Author information


  1. iSAEC, 8770 West Bryn Mawr Avenue, Suite 1300, Chicago, Illinois 60631, USA.

    • Arthur L. Holden
  2. iSAEC and at the S.J. Quinney College of Law, and Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA.

    • Jorge L. Contreras
  3. iSAEC Scientific Management Committee and at Pfizer, New London, Connecticut 06320, USA.

    • Sally John
  4. iSAEC Scientific Management Committee and at GlaxoSmithKline, Research Triangle Park, North Carolina 27709–3398, USA.

    • Matthew R. Nelson


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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Arthur L. Holden.

Supplementary information

PDF files

  1. 1.

    Supplementary information S1 (table)

    Summary of case enrolment by iSAEC and status of phase 2 pipeline

  2. 2.

    Supplementary information S2 (Box)

    Publications from the International Serious Adverse Events Consortium to date (as of September 2014)

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