The sonic hedgehog protein is involved in cancer progression. To identify new sonic hedgehog inhibitors, Petrova et al. screened for a small-molecule inhibitor of Hedgehog acetyltransferase, an enzyme involved in sonic hedgehog palmitoylation and regulation of sonic hedgehog signalling. From a series of hits generated from initial screens, four lead compounds were selected based on their potency and drug-like scaffold, one of which was shown to inhibit autocrine and paracrine sonic hedgehog signalling in cells.
ORIGINAL RESEARCH PAPER
Petrova, E. et al. Inhibitors of Hedgehog acetyltransferase block Sonic Hedgehog signaling. Nature Chem. Biol. 17 Feb 2013 (doi:10.1038/nchembio.1184)
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Harrison, C. New inhibitors of sonic hedgehog signalling. Nat Rev Drug Discov 12, 264 (2013). https://doi.org/10.1038/nrd3985
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DOI: https://doi.org/10.1038/nrd3985