RNA interference is a potentially useful way to study cancer targets in vivo, but is hampered by delivery issues. Using the ID4 oncogene in ovarian cancer as an example, Ren et al. developed a tumour-penetrating nanocomplex made up of small interfering RNA (siRNA) complexed with a tumour-penetrating and membrane-translocating peptide, which enabled the specific delivery of siRNA deep into the ovarian tumour parenchyma. Treatment of ovarian tumour-bearing mice with the ID4-specific nanocomplex suppressed tumour growth and improved survival.
ORIGINAL RESEARCH PAPER
Ren Y. et al. Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci. Transl. Med. 4, 147ra112 (2012)
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Harrison, C. Tumour delivery of RNA interference. Nat Rev Drug Discov 11, 750 (2012). https://doi.org/10.1038/nrd3862
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DOI: https://doi.org/10.1038/nrd3862