MYC oncogenes are implicated in various cancers, but are considered difficult to 'drug' as they encode transcription factors. Toyoshima et al. used a functional genomic screen to identify genes that, when expressed with oncogenic MYC, provide a synthetic lethal interaction. Several genes were identified that selectively induced the accumulation of DNA damage in MYC-expressing cells. Validation studies showed that inhibition of casein kinase 1χ, expression of which correlated with MYC expression in human cancers, prevented the growth of MYC-amplified neuroblastoma xenografts.
ORIGINAL RESEARCH PAPER
Toyoshima, T. et al. Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc. Natl Acad. Sci. USA 109, 9545–9550 (2012)Article
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Harrison, C. Synthetic lethality enables targeting of MYC. Nat Rev Drug Discov 11, 602 (2012). https://doi.org/10.1038/nrd3816
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DOI: https://doi.org/10.1038/nrd3816