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Obesity and diabetes

An FGFR antibody with long-lasting effects

Nature Reviews Drug Discovery volume 11, pages 106–107 (2012)Cite this article

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The authors used phage display technology to generate two monoclonal antibodies that had subnanomolar affinity for FGFR1b and FGFR1c but did not bind to any other FGFR isoforms or to the FGF co-receptor β-klotho. One antibody — R1MAb1 — was chosen for further studies.

In a mouse model of diabetes (db/db mice), a single injection of R1MAb1 normalized blood glucose levels for more than 1 week, and levels remained lower than in control mice (immunolgobulin G-treated mice) for more than 30 days, including at time points when serum concentrations of R1MAb1 could not be detected. Administration of R1MAb1 also lowered fasting glucose levels (but did not cause hypoglycaemia) and lowered fasting serum insulin levels, suggesting that R1MAb1 had insulin-sensitizing effects.

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References

ORIGINAL RESEARCH PAPER

  1. Wu, A. L. et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci. Transl. Med. 3, 113ra126 (2011)Article

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FURTHER READING

  1. Beenken, A. & Mohammadi, M. The FGF family: biology, pathophysiology and therapy. Nature Rev. Drug Discov. 8, 235–253 (2009)

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Authors
  1. Charlotte Harrison
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Harrison, C. An FGFR antibody with long-lasting effects. Nat Rev Drug Discov 11, 106–107 (2012). https://doi.org/10.1038/nrd3660

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