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In November 2011, ruxolitinib (Jakafi; Incyte/Novartis), a small-molecule inhibitor of Janus kinases, was approved by the US Food and Drug Administration for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythaemia vera myelofibrosis and post-essential thrombocythaemia myelofibrosis.

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Figure 1: Ruxolitinib.


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Correspondence to Ruben A. Mesa, Uma Yasothan or Peter Kirkpatrick.

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The authors declare no competing financial interests.

Supplementary information

Supplementary information Figure S1

First-line therapy of myelofibrosis in 2012. (PDF 702 kb)

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Mesa, R., Yasothan, U. & Kirkpatrick, P. Ruxolitinib. Nat Rev Drug Discov 11, 103–104 (2012).

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