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The impact of mergers on pharmaceutical R&D

Nature Reviews Drug Discovery volume 10, pages 559560 (2011) | Download Citation


Mergers and acquisitions in the pharmaceutical industry have substantially reduced the number of major companies over the past 15 years. The short-term business rationale for this extensive consolidation might have been reasonable, but at what cost to research and development productivity?

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  1. 1.

    et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Rev. Drug Discov. 9, 203–214 (2010).

  2. 2.

    Rebuilding the R&D engine in Big Pharma. Harvard Bus. Rev. 86, 68–76 (2008).

  3. 3.

    Lessons from 60 years of pharmaceutical innovation. Nature Rev. Drug Discov. 8, 959–968 (2009).

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  1. John L. LaMattina is the former President of Pfizer Global Research and Development, and is currently Senior Partner at Puretech Ventures, Boston, Massachusetts 02116, USA.

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Competing interests

The author declares no competing financial interests.

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    Approvals of new chemical entities by the US FDA: 1940–2010

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