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In October 2009, pazopanib (Votrient; GlaxoSmithKline) — a multikinase inhibitor with targets that include vascular endothelial growth factor receptors — was approved by the US FDA for the treatment of advanced renal cell carcinoma.

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Figure 1: Targeting growth factor signalling in renal cell carcinoma.


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Competing interests

R.M.B. has received honoraria and acted as a consultant for Pfizer, Novartis and Genentech, and has acted as a consultant for GSK and Bayer.

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Bukowski, R., Yasothan, U. & Kirkpatrick, P. Pazopanib. Nat Rev Drug Discov 9, 17–18 (2010).

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