Abstract
In September 2009, telavancin (Vibativ; Theravance/Astellas Pharma), a lipoglycopeptide antibiotic, was approved by the US FDA for the treatment of adult patients with complicated skin and skin structure infections.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Van Bambeke, F. Glycopeptides in clinical development: pharmacological profile and clinical perspectives. Curr. Opin. Pharmacol. 4, 471–478 (2004).
Leadbetter, M. R. et al. Hydrophobic vancomycin derivatives with improved ADME properties: discovery of telavancin (TD-6424). J. Antibiot. 57, 326–336 (2004).
Hegde, S. S. et al. Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against Gram-positive bacteria. Antimicrob. Agents Chemother. 48, 3043–3050 (2004).
Food and Drug Administration. FDA labelling information. FDA website [online] (2009).
Higgins, D. L. et al. Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49, 1127–1134 (2005).
Lunde, C. S. et al. Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II. Antimicrob. Agents Chemother. 53, 3375–3383 (2009).
Krause, K. M. et al. In vitro activity of telavancin against resistant Gram-positive bacteria. Antimicrob. Agents Chemother. 52, 2647–2652 (2008).
Stryjewski, M. E. et al. Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by Gram-positive organisms. Clin. Infect. Dis. 46, 1683–1693 (2008).
King, M. D. et al. Emergence of community-acquired methicillin-resistant Staphylococcus aureus USA 300 clone as the predominant cause of skin and soft-tissue infections. Ann. Intern. Med. 144, 309–317 (2006).
Moran, G. J. et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N. Engl. J. Med. 355, 666–674 (2006).
Wang, G. et al. Increased vancomycin MICs for Staphylococcus aureus clinical isolates from a university hospital during a 5-year period. J. Clin. Microbiol. 44, 3883–3886 (2006).
Tenover, F. C. Vancomycin-resistant Staphylococcus aureus: a perfect but geographically limited storm? Clin. Infect. Dis. 46, 675–677 (2008).
Sun, H. K. et al. Tissue penetration of telavancin after intravenous administration in healthy subjects. Antimicrob. Agents Chemother. 50, 788–790 (2006).
IMS MIDAS (IMS Health, 2009).
Sanderson, I. et al. Specialty Pharmaceuticals (Cowen and Company, 14 Sep 2009).
Urist, M. & Harr, S. JP Morgan North America Equity Research Report (JP Morgan & Chase, 23 Jul 2009).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
G.R.C. is the Principal Investigator for trials with telavancin. M.E.S. has received research grants from Theravance Inc. and currently he is a consultant to Theravance. M.E.S. has provided consulting services to Astellas in the past.
Rights and permissions
About this article
Cite this article
Corey, G., Stryjewski, M., Weyenberg, W. et al. Telavancin. Nat Rev Drug Discov 8, 929–930 (2009). https://doi.org/10.1038/nrd3051
Issue Date:
DOI: https://doi.org/10.1038/nrd3051
This article is cited by
-
A brief history of antibiotics and select advances in their synthesis
The Journal of Antibiotics (2018)
-
Glycopeptide antibiotics: Back to the future
The Journal of Antibiotics (2014)
-
Prospects for new antibiotics: a molecule-centered perspective
The Journal of Antibiotics (2014)
-
The re-emerging role of microbial natural products in antibiotic discovery
Antonie van Leeuwenhoek (2014)
-
Case Report: Artificial Elevation of Prothrombin Time by Telavancin
Clinical Orthopaedics & Related Research (2013)