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TLR-targeted therapeutics

Nature Reviews Drug Discovery volume 4, pages 879–880 (2005)Cite this article

Descriptions of the immune system frequently use military analogies, from the 'evolutionary arms race' between microbes and the immune system to the 'surgical strikes' provided by highly specific antibodies. If CD4 T cells are the generals, CD8 T cells the cavalry and B cells the artillery of the immune system, then the innate immune system is the militia, holding off invaders initially and alerting the professionals. Toll-like receptors (TLRs) are part of the innate immune system, and help serve as the first line of defence.

New understanding of innate immunity

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Figure 1: Estimated market size for selected Toll-like receptor indications.

References

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  1. biotech analysts at J.P. Morgan, 50 Rowes Wharf, Boston, 02110, Massachusetts, USA

    Eric S. Hoffman, Richard E. T. Smith & Ronald C. Renaud Jr

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  1. Eric S. Hoffman
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  2. Richard E. T. Smith
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  3. Ronald C. Renaud Jr
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Hoffman, E., Smith, R. & Renaud, R. TLR-targeted therapeutics. Nat Rev Drug Discov 4, 879–880 (2005). https://doi.org/10.1038/nrd1880

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